This book focuses on clinical series of diabetes mellitus. World are facing a pandemic of diabetes. The International Diabetes Federation estimates that over 400 million adults worldwide have diabetes, and that the number will rise to over 600 million by 2040. Every country is affected by this disease and its many complications, including heart disease, kidney disease, blindness, and neuropathy. There are over 340 million individuals with impaired glucose tolerance who are at significant risk of converting to diabetes without proper diagnosis and treatment. This book consists of 14 chapters, which include personal prescription of exercise and diabetes, medical nutrition therapy for adults with diabetes and related topics, management of type 2 diabetes mellitus, inpatient management of diabetes, clinical pearls for the management of diabetes in pregnancy, diabetes and cardiovascular disease, update on the management of diabetic retinopathy, diabetic neuropathy, diabetic nephropathy, hypoglycemia in diabetes, bariatric surgery and its role in the management of diabetes, retaining and regaining pancreatic β-cells to treat diabetes, and role of nonphysician healthcare providers in diabetes management. Hope is that readers will find useful current, practical advice for managing diabetes and its complications, and will be able to utilize this book as a reference for many years to come.